Omar Marmoush and Nico O'Reilly's stellar cameos at Bournemouth have earned both a starting berth against Leicester.
The pair are joined by Nico, Savinho, Jeremy Doku and Jack Grealish as Pep Guardiola makes six changes from the weekend.
Oscar Bobb makes a welcome return as a substitute after almost eight months out.
Making way is the injured Erling Haaland, while Mateo Kovacic, Kevin De Bruyne, Bernardo and Phil Foden start on the bench.
Abdukodir Khusanov is not in the matchday squad as he is given a well-earned rest.
Line-ups
CITY: Ederson, Nunes, Dias (C), Gvardiol, O’Reilly, Nico, Gundogan, Savinho, Grealish, Doku, Marmoush
SUBS:: Ortega Moreno, Kovacic, De Bruyne, Bernardo, Reis, Foden, Bobb, Lewis, McAtee
LEICESTER CITY: Hermansen, Justin, Faes, Coady, Kristiansen, Thomas, Soumare, Ndidi, El Khanouss, Daka, Vardy (C)
Subs: Stolarczyk, Coulibaly, Okoli, Ricardo, Skipp, De Cordova-Reid, Buonanotte, Mavididi, Ayew
Formation & probable tactics
Josko Gvardiol will partner Ruben Dias as the back four central pairing, with O'Reilly on the left and Mathues Nunes on the right.
Expect Grealish to take on a No.10 role, alongside Ilkay Gundogan with Nico the anchor in midfield.
Savinho and Doku will flank Marmoush up front in a 4-3-3.
As always, it will be a fluid formation with both wingers likely to swap flanks throughout the game.
Huge game for O'Reilly and Grealish
Nico O'Reilly's superb performance at Bournemouth has deservedly earned him a first Premier League start against the Foxes.
The 20-year-old has impressed whenever he has been called upon by Guardiola and now he has the opportunity to push his first team claims even further.
Jack Grealish has had to be patient in recent weeks as he waited for a first team return - and he will do so now in a position he excelled in earlier this season - centre midfield.
Both will look to grasp their opportunity with the Manchester derby next on the agenda this weekend - and beyond.
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