March Madness 2025 odds, matchups: Opening lines for first-round NCAA tournament games
March Madness is here and the 2025 NCAA tournament bracket has been revealed. Duke, Florida, Houston and Auburn are the four No. 1 overall seeds, with Auburn grabbing the top overall seed. Florida is the betting favorite to cut down the nets with +350 odds at BetMGM, with Duke (+360) and Auburn (+400) right behind the Gators.
While you'll have several days to fill out your bracket, the odds for every first-round March Madness games are already up at sportsbooks and moving, as bettors place their wagers.
[Yahoo Fantasy Bracket Mayhem is back: Enter for a shot to win up to $50K]
Below you'll find the odds for every first-round game at BetMGM, sorted by region.
East Region
No. 1 Duke vs. No. 16 Mount St. Mary's/American University
No. 8 Mississippi State vs. No. 9 Baylor (-1.5)
No. 5 Oregon (-4.5) vs. No. 12 Liberty
No. 4 Arizona (-15.5) vs. No. 13 Akron
No. 6 BYU (-3.5) vs. No. 11 VCU
No. 3 Wisconsin (-17.5) vs. No. 14 Montana
No. 7 St. Mary's (-5.5) vs. No. 10 Vanderbilt
No. 2 Alabama (-22.5) vs. No. 15 Robert Morris
Midwest Region
No. 1 Houston (-27.5) vs. No. 16 SIU-Edwardsville
No. 8 Gonzaga (-4.5) vs. No. 9 Georgia
No. 5 Clemson (-7.5) vs. No. 12 McNeese State
No. 4 Purdue (-10.5) vs. No. 13 High Point
No. 6 Illinois vs. No. 11 Texas/Xavier
No. 3 Kentucky (-10.5) vs. No. 14 Troy
No. 7 UCLA (-5.5) vs. No. 10 Utah State
No. 2 Tennessee (-19.5) vs. No. 15 Wofford
South Region
No. 1 Auburn vs. No. 16 St. Francis (PA)/Alabama State
No. 8 Louisville (-1.5) vs. No. 9 Creighton
No. 5 Michigan (-3.5) vs. No. 12 UC San Diego
No. 4 Texas A&M (-7.5) vs. No. 13 Yale
No. 6 Ole Miss vs. No. 11 UNC/SDSU
No. 3 Iowa State (-13.5) vs. No. 14 Lipscomb
No. 7 Marquette (-3.5) vs. No. 10 New Mexico
No. 2 Michigan State (18.5) vs. No. 15 Bryant
West Region
No. 1 Florida (-28.5) vs. No. 16 Norfolk State
No. 8 UConn (-4.5) vs. No. 9 Oklahoma
No. 5 Memphis vs. No. 12 Colorado State (-3.5)
No. 4 Maryland (-11.5) vs. No. 13 Grand Canyon
No. 6 Missouri (-6.5) vs. No. 11 Drake
No. 3 Texas Tech (-15.5) vs. No. 14 NC-Wilmington
No. 7 Kansas (-5.5) vs. No. 10 Arkansas
No. 2 St. John's (-17.5) vs. No. 15 Omaha
Read more at Yahoo Sports
-
2025 NCAA Tournament odds, lines: Game spreads for every First Four, first-round matchup in March Madness
The opening odds and game spreads for the 2025 NCAA TournamentCBS Sports - 10h -
Oregon vs. Vanderbilt in March Madness: Prediction for 2025 NCAA Tournament opener
It's Oregon vs. Vanderbilt in the first round of the 2025 Women's NCAA Tournament. Here's our prediction for the March Madness basketball game.Yahoo Sports - 10h -
Oregon's March Madness opponent is Liberty to open 2025 NCAA Tournament
It's Oregon vs Liberty in March Madness to open 2025 NCAA Tournament bracket.Yahoo Sports - 14h -
Florida vs Norfolk St matchup officially set. Time, date for March Madness 1st round game
What time does Florida basketball play Norfolk State in March Madness Round of 64? Here’s time, date, TV for 2025 NCAA Tournament opener.Yahoo Sports - 12h -
Louisville vs Nebraska game time set for 2025 NCAA Tournament opener
What time does Louisville women’s basketball play Nebraska in March Madness? Here’s the game time for 2025 NCAA Tournament opener.Yahoo Sports - 10h -
Kentucky vs Liberty game time set for 2025 NCAA Tournament opener
What time does Kentucky basketball play Liberty in Women's March Madness? Here’s the game time for 2025 NCAA Tournament opener.Yahoo Sports - 9h -
Kentucky vs Liberty prediction in March Madness: Prediction for 2025 NCAA Tournament opener
It’s Kentucky vs Liberty in the first round of the 2025 Women’s NCAA Tournament. Here’s our prediction for the March Madness basketball game.Yahoo Sports - 10h -
Alabama basketball’s March Madness opponent is Green Bay to open NCAA Tournament bracket
It’s Alabama vs. Green Bay in March Madness to open its 2025 NCAA Tournament women’s bracket. Here’s what to know about the first-round game.Yahoo Sports - 1h -
Marquette basketball’s March Madness opponent is New Mexico to open 2025 NCAA tournament bracket
It’s Marquette basketball vs. New Mexico in March Madness to open its 2025 NCAA tournament men’s bracket. Here’s what to know about the first-round game in Cleveland.Yahoo Sports - 15h -
Drake basketball’s March Madness opponent is Missouri to open 2025 NCAA Tournament bracket
It’s Drake basketball vs. Missouri in March Madness to open its 2025 NCAA Tournament men’s bracket. Here’s what to know about the first-round game in Wichita.Yahoo Sports - 14h -
Michigan State vs. Harvard game time set for 2025 NCAA Tournament opener
What time does Michigan State women’s basketball play Harvard in March Madness? Here’s the game time for 2025 NCAA Tournament opener.Yahoo Sports - 10h -
Michigan women vs Iowa State or Princeton game time set for 2025 NCAA Tournament opener
What time does Michigan women’s basketball play Iowa State or Princeton in March Madness? Here’s the game time for 2025 NCAA Tournament opener.Yahoo Sports - 9h -
Oregon women's basketball vs. Vanderbilt game time set for 2025 NCAA Tournament opener
What time does Oregon women's basketball play Vanderbilt in March Madness? Here's the game time for 2025 NCAA Tournament opener.Yahoo Sports - 9h -
Game time set for UW-Green Bay women's basketball vs Alabama in 2025 NCAA tournament opener
What time does UW-Green Bay women's basketball play Alabama in March Madness? Here’s the game time for 2025 NCAA Tournament opener.Yahoo Sports - 9h -
LSU, Kim Mulkey vs San Diego State game time set for 2025 NCAA Tournament opener
What time does LSU women's basketball play San Diego State in March Madness? Here's the game time for 2025 NCAA Tournament opener.Yahoo Sports - 9h -
Lady Vols basketball’s March Madness opponent is South Florida to open NCAA Tournament
Lady Vols basketball versus South Florida in March Madness to open its 2025 NCAA Tournament bracket. Here is what to know about the first-round game.Yahoo Sports - 12h -
South Carolina vs Tennessee Tech prediction in March Madness: Prediction for 2025 NCAA opener
It's South Carolina vs Tennessee Tech in the first round of the 2025 Women’s NCAA Tournament. Here’s our prediction for the March Madness basketball game.Yahoo Sports - 10h -
March Madness 2025 betting, odds, lines: Three key storylines for the NCAA tournament
Here are three storylines that stood out after the bracket was revealed and sportsbooks put up their Round 1 odds.Yahoo Sports - 10h -
Ohio State women's basketball vs. Montana State game time set for NCAA Tournament opener
What time does Ohio State women’s basketball play Montana State in March Madness? Here’s the game time for 2025 NCAA Tournament opener.Yahoo Sports - 9h -
Women’s March Madness projections 2025: Full NCAA Tournament bracket odds
Welcome to ’s 2025 women’s NCAA Tournament projections, where you’ll find every team’s chances of advancing through each weekend of March Madness and cutting down the nets in Tampa on April 6. ...Yahoo Sports - 9h -
Michigan State is 2-seed in March Madness, opponent is Bryant in NCAA tournament
It’s Michigan State basketball vs. Bryant in March Madness to open the 2025 NCAA tournament in the South region.Yahoo Sports - 15h -
Vermont women's basketball will face NC State to open March Madness: Bracket update
It's UVM women's basketball vs. NC State in March Madness to open the 2025 NCAA Tournament. Here’s what to know about the first-round game in RaleighYahoo Sports - 12h -
How to run your 2025 March Madness pool: Play for prizes and create your own NCAA Tournament game
The CBS Sports 2025 NCAA Men's and Women's Games have returned for March Madness 2025 office pools.CBS Sports - 22h -
2025 NCAA Tournament schedule: March Madness bracket, game dates, locations, tip times, TV channels
Check out the master schedule for the NCAA Tournament so you can watch all the March Madness 2025 actionCBS Sports - 10h -
Ohio State women March Madness: Buckeyes face Montana State to open 2025 NCAA Tournament
It’s Ohio State women's basketball vs. Montana State to open NCAA Tournament bracket. Here’s what to know about the first-round game in Columbus.Yahoo Sports - 12h -
2025 March Madness odds: Duke, Florida have best odds to win NCAA Tournament after bracket is set
Duke and Florida have better odds to win the NCAA Tournament than Auburn, the No. 1 overall seedCBS Sports - 12h -
March Madness: How to watch and what to watch for in the 2025 NCAA Tournament
March Madness is here and Auburn is the No. 1 overall seed in the men's NCAA Tournament. The beloved annual tradition that is the NCAA Tournament opens this week. Tens of thousands will fill out ...Yahoo Sports - 12h -
Women’s March Madness 2025 national title odds: South Carolina, UConn early betting favorites
Two of the most storied programs in women’s college basketball are on top of the national championship odds after the 2025 NCAA Tournament bracket was released. South Carolina and Connecticut ...Yahoo Sports - 9h -
Oklahoma State women's basketball will face South Dakota State to open March Madness
It’s Oklahoma State women’s basketball vs. South Dakota State in March Madness to open the 2025 NCAA Tournament. Here’s what to know about the first-round game in Storrs, Conn.Yahoo Sports - 12h -
Oregon vs. Liberty officially set. Time, date for March Madness first round game
What time does Oregon basketball play Liberty in March Madness Round of 64? Here’s time, date, TV for 2025 NCAA Tournament opener.Yahoo Sports - 13h -
Louisville vs Creighton officially set. Here’s time, date for March Madness Round of 64 game
What time does Louisville basketball play Creighton in March Madness Round of 64? Here’s the time, date for 2025 NCAA Tournament opener.Yahoo Sports - 12h -
Vanderbilt vs. Saint Mary's officially set. Time, date for March Madness first round game
What time does Vanderbilt basketball play Saint Mary's in March Madness Round of 64? Here’s time, date, TV for 2025 NCAA Tournament opener.Yahoo Sports - 12h -
I picked every game in March Madness bracket. Here's who wins 2025 NCAA Tournament | Estes
Take a peek at my March Madness bracket predictions and picks for every NCAA Tournament game from the First Four to the Final Four.Yahoo Sports - 7h -
Where Cleveland's first/second-round matchups stand in March Madness bracket predictions
Cleveland first/second-round March Madness bracketology and predictions on Selection Sunday, when the 2025 NCAA Tournament bracket will be revealed.Yahoo Sports - 1d -
3 March Madness upset predictions, bracket-busters for 2025 NCAA women's bracket
Which games in the 2025 NCAA women's tournament will bust your bracket? Our March Madness upset predictions are inYahoo Sports - 2h -
Start time, TV channel announced for Alabama vs. Robert Morris NCAA Tournament game
Alabama will open March Madness against Robert Morris in the 2025 NCAA Tournament. Here's what channel you'll need to watch the Crimson Tide.Yahoo Sports - 4h -
March Madness 2025 odds, lines, favorites: South Carolina opens women's tournament as a slight favorite over UConn
The Gamecocks are +270 to win it all but aren't the No. 1 overall seed.Yahoo Sports - 12h -
Marquete basketball tickets in 2025 NCAA tournament: Prices, how to buy
Want to buy tickets to Marquette basketball’s NCAA tournament 2025 opener? Here’s how, including prices for March Madness.Yahoo Sports - 14h -
Missouri basketball tickets in 2025 NCAA Tournament: Prices, how to buy
Want to buy tickets to Missouri basketball’s NCAA Tournament 2025 opener? Here’s how, including prices for March Madness.Yahoo Sports - 13h
More from Yahoo Sports
-
USC NCAA Tournament opener will be on Saturday, March 22 at Galen Center
The Trojans will open the tournament against UNC Greensboro on Saturday at high noon in Los AngelesYahoo Sports - 11m -
PSG win over Marseille marred by homophobic, racist chants. It's an ongoing problem in French soccer
A French campaign group has called on the country's authorities to punish homophobic and racist chanting after the biggest match in the league between Paris Saint-Germain and Marseille was marred ...Yahoo Sports - 12m -
Can Oregon basketball reach Final Four in March Madness bracket? Our prediction
Can Oregon basketball reach NCAA bracket’s Final Four? Our 2025 March Madness predictions show how Ducks can make run in tournament.Yahoo Sports - 12m -
Broncos have 35 players set to become free agents in 2026
The Broncos have 35 players scheduled to become free agents in 2026.Yahoo Sports - 13m -
NFL analyst says Rams overpaid for this free agent
The Rams have spent a lot of money this offseason, but did they overpay?Yahoo Sports - 13m
More in Sports
-
March Madness 2025: Duke's Cooper Flagg, Texas' Tre Johnson headline list of top freshmen in the tournament
Flagg, the projected No. 1 pick in the 2025 NBA Draft, headlines a star-studded group of freshmen in the NCAA TournamentCBS Sports - 6m -
NCAA Tournament fields set; TPC playoff underway; Bengals extend star wide receivers
Auburn has the top overall seed in the men's field, while UCLA leads the women's drawCBS Sports - 7m -
2025 MLB Opening Day starter tracker: Paul Skenes gets call for Pirates, Astros go with Framber Valdez again
The regular season is almost upon us and managers are getting their ducks (and rotations) in a rowCBS Sports - 9m -
USC NCAA Tournament opener will be on Saturday, March 22 at Galen Center
The Trojans will open the tournament against UNC Greensboro on Saturday at high noon in Los AngelesYahoo Sports - 11m -
PSG win over Marseille marred by homophobic, racist chants. It's an ongoing problem in French soccer
A French campaign group has called on the country's authorities to punish homophobic and racist chanting after the biggest match in the league between Paris Saint-Germain and Marseille was marred ...Yahoo Sports - 12m