March Madness 2025 odds, matchups: Opening lines for first-round NCAA tournament games
March Madness is here and the 2025 NCAA tournament bracket has been revealed. Duke, Florida, Houston and Auburn are the four No. 1 overall seeds, with Auburn grabbing the top overall seed. Florida is the betting favorite to cut down the nets with +350 odds at BetMGM, with Duke (+360) and Auburn (+400) right behind the Gators.
While you'll have several days to fill out your bracket, the odds for every first-round March Madness games are already up at sportsbooks and moving, as bettors place their wagers.
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Below you'll find the odds for every first-round game at BetMGM, sorted by region.
East Region
No. 1 Duke vs. No. 16 Mount St. Mary's/American University
No. 8 Mississippi State vs. No. 9 Baylor (-1.5)
No. 5 Oregon (-4.5) vs. No. 12 Liberty
No. 4 Arizona (-15.5) vs. No. 13 Akron
No. 6 BYU (-3.5) vs. No. 11 VCU
No. 3 Wisconsin (-17.5) vs. No. 14 Montana
No. 7 St. Mary's (-5.5) vs. No. 10 Vanderbilt
No. 2 Alabama (-22.5) vs. No. 15 Robert Morris
Midwest Region
No. 1 Houston (-27.5) vs. No. 16 SIU-Edwardsville
No. 8 Gonzaga (-4.5) vs. No. 9 Georgia
No. 5 Clemson (-7.5) vs. No. 12 McNeese State
No. 4 Purdue (-10.5) vs. No. 13 High Point
No. 6 Illinois vs. No. 11 Texas/Xavier
No. 3 Kentucky (-10.5) vs. No. 14 Troy
No. 7 UCLA (-5.5) vs. No. 10 Utah State
No. 2 Tennessee (-19.5) vs. No. 15 Wofford
South Region
No. 1 Auburn vs. No. 16 St. Francis (PA)/Alabama State
No. 8 Louisville (-1.5) vs. No. 9 Creighton
No. 5 Michigan (-3.5) vs. No. 12 UC San Diego
No. 4 Texas A&M (-7.5) vs. No. 13 Yale
No. 6 Ole Miss vs. No. 11 UNC/SDSU
No. 3 Iowa State (-13.5) vs. No. 14 Lipscomb
No. 7 Marquette (-3.5) vs. No. 10 New Mexico
No. 2 Michigan State (18.5) vs. No. 15 Bryant
West Region
No. 1 Florida (-28.5) vs. No. 16 Norfolk State
No. 8 UConn (-4.5) vs. No. 9 Oklahoma
No. 5 Memphis vs. No. 12 Colorado State (-3.5)
No. 4 Maryland (-11.5) vs. No. 13 Grand Canyon
No. 6 Missouri (-6.5) vs. No. 11 Drake
No. 3 Texas Tech (-15.5) vs. No. 14 NC-Wilmington
No. 7 Kansas (-5.5) vs. No. 10 Arkansas
No. 2 St. John's (-17.5) vs. No. 15 Omaha
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