With nine games in the Championship and half a dozen in League One, Tuesday could be one of the most significant midweek matchdays this season.
The Championship's top three - Burnley, Sheffield United and Leeds - are all in action. Any one of those teams could finish the night at the summit.
In League One, runaway leaders Birmingham City know a victory will send them up with six matches still remaining.
And it feels like the last-chance saloon for third-placed Wycombe as they play their game in hand on second-placed Wrexham.
Here's what to look out for...
In a hugely important game for sides at both ends of the Championship table, pole sitters Burnley travel to Derby, whose recent resurgence under John Eustace which saw them win four in four, was checked by defeat to Swansea on Saturday.
The Clarets will seek to keep destiny in their own hands having regained top spot in the table for the first time since 19 October with a win over Coventry at the weekend.
But manager Scott Parker told BBC Radio Lancashire that despite a run of 27 games unbeaten he does not expect any easy games from now until May.
"They [Derby] will be tough opposition but you get to this point of the season and every game is a tough game," he said.
"A lot of teams have got different things that they are fighting for whether that is promotion, relegation or the play-offs but hopefully we will go there and get the job done."
Sheffield United, who might be rueing that two-point deduction for late transfer payments last season with each passing week, host ninth-placed Millwall.
Could those two points prove the difference at the finishing line?
And spare a thought for Leeds, whose nervous fans are barely able to watch from behind their cushions as the spectre of the play-offs looms once again following a run of just seven points from a possible 18.
It is a wobble which has seen them slip out of the top two for the first time in five months and makes Tuesday's trip to a Middlesbrough side fresh from five wins in seven and intent on securing their own play-off place, look tricky to say the least.
Eighth-placed West Brom travel to Bristol City aiming to bump the Robins out of sixth spot.
Tony Mowbray's men will have to locate their shooting boots after failing to find the net in their last two outings, despite dominating against Sunderland on Saturday.
If the Baggies are stuttering as the finish line approaches, with no wins in four, Mowbray told BBC Radio WM it is not for lack of effort
"We are frustrated but I don't feel the need to apologise as everyone is giving everything at the moment and the results are not falling our way but we have to dig in really deep," he said.
If they do manage to chisel out a win, Coventry ...
