Tottenham will play rivals Arsenal in Hong Kong on Thursday, 31 July as part of their pre-season tour.
It will be the first north London derby to take place outside of London and will be hosted at the new Kai Tak Stadium.
Chief revenue officer, Ryan Norys said: "There are few bigger occasions in English football than a north London derby and to play this fixture in Hong Kong will be a huge occasion for our passionate fanbase across Asia, as well as providing ideal preparation for the team ahead of the new season.
"As is tour tradition, the club will be involved in so much more than the match itself when we visit, supporting charitable causes, celebrating local culture, delivering football clinics for young people and engaging with fans and partners.
"We cannot wait to visit such a beautiful place once again."