Roma start Lorenzo Pellegrini and Matias Soulé behind Artem Dovbyk as they seek a seventh straight Serie A victory away to Nikola Krstovic’s Lecce.
It kicks off at the Stadio Via del Mare at 19.45 GMT.
The Giallorossi are now out of the Europa League and Coppa Italia, but are climbing up the table after six consecutive Serie A wins.
However, they will be without Paulo Dybala for the rest of the season following surgery on a tendon tear, so Soulé has to step up and support Dovbyk.
Zeki Celik, Devyne Rensch and Saud Abdulhamid are all injured, so Alexis Saelemaekers takes the right wing.
Leandro Paredes is rested after international duty with Argentina.
Lecce are struggling badly after four consecutive defeats, so they are only out of the relegation zone on goal difference.
They scraped two points from the last six rounds and the season is over for Filip Marchwinski following knee surgery.
Krstovic gets support from Santiago Pierotti and Jesper Karlsson.
Lecce vs. Roma official line-ups
Lecce: Falcone; Guilbert, Baschirotto, Gaspar, Gallo; Coulibaly, Ramadani; Pierotti, Helgason, Karlson; Krstovic
Roma: Svilar; Mancini, Hummels, N’Dicka; Saelemaekers, Cristante, Koné, Angelino; Soulé, Pellegrini; Dovbyk
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