Antonio Conte is reportedly undecided on which system Napoli should use against Milan as he welcomes back David Neres in attack.
It kicks off at 20:45 CET (18:45 GMT) at the Stadio Diego Maradona in Naples.
The Brazilian is set to return from injury but should only come on in the second-half, meaning Conte could initially stick with the 3-5-2 formation that he had recently switched to because of his absence, according to Sky Sport Italia.
Giacomo Raspadori is expected to partner with Romelu Lukaku in attack, while Matteo Politano will operate as a right wing-back. However, La Gazzetta dello Sport suggests he could take on a more advanced role in a 4-3-3 formation.
Midfielder Zambo Anguissa is not fully fit, so Billy Gilmour is expected to replace him in midfield, joining Stanislav Lobotka and Scott McTominay to complete the trio.
Milan coach Sergio Conceiçao has several doubts about his starting lineup, as Sky Sport Italia reports that Rafael Leao could begin on the bench, with Joao Felix starting on the left in the Rossoneri’s attacking trident.
Youssouf Fofana could be benched for a third consecutive Serie A match, with both Ruben Loftus-Cheek and Warren Bondo likely to start alongside the ever-present Tijjani Reijnders against the Partenopei.
Tammy Abraham is competing with Santiago Gimenez for a place up front, with the former Roma striker currently considered the favourite for the spot.
Napoli vs Milan – where to watch on TV
The Stadio Diego Maradona showdown will be broadcast live on TNT Sports 1 and is also available to watch through OneFootball in the UK. Fans in the USA can tune in via Paramount+.
Napoli vs Milan – probable line-ups
Napoli (3-5-2): Meret; Di Lorenzo, Rrahmani, Buongiorno; Politano, Gilmour, Lobotka, McTominay, Olivera; Lukaku, Raspadori.
Milan (4-3-3): ...
