Its Friday, April 4 and the Padres (7-0) are in the Windy City to take on the Cubs (5-4) in Game 1 of their weekend series.
Randy Vásquez is slated to take the mound for San Diego against Shota Imanaga for Chicago.
The Cubs are back at Wrigley following a three-game smackdown of the Athletics in Sacramento. Chicago outscored the Athletics 35-9 in the series. Wednesday, Seiya Suzuki homered twice and drove in five runs to power the Cubs to a 10-2 win.
San Diego is one of two remaining unbeaten teams in baseball. The Padres swept the Guardians earlier this week. Jackson Merrill picked up two hits and a couple of RBIs in Wednesday's 5-2 win.
Lets dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Padres at Cubs
- Date: Friday, April 4, 2025
- Time: 2:20PM EST
- Site: Wrigley Field
- City: Chicago, IL
- Network/Streaming: Padres.TV, Marquee
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Padres at the Cubs
The latest odds as of Thursday:
- Moneyline: Padres (+140), Cubs (-165)
- Spread: Cubs -1.5
- Total: 6.5 runs
Probable starting pitchers for Padres at Cubs
- Pitching matchup for April 4, 2025: Randy Vásquez vs. Shota Imanaga
- Padres: Randy Vásquez (0-0, 0.00 ERA)
Last outing: 3/29 vs. Braves - 6 IP, 0ER, 4H, 4BB, 3Ks - Cubs: Shota Imanaga (1-0, 0.82 ERA)
Last outing: 3/29 at DBacks - 7 IP, 1ER, 3H, 2BB, 4Ks
- Padres: Randy Vásquez (0-0, 0.00 ERA)
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Top betting trends & insights to know ahead of Padres at Cubs
- Thanks to a series in Sacramento, the Cubs run differential is +14 for the season
- Padres' pitchers have allowed a mere 11 runs in 7 games
- San Diego has thrown three shutouts already this season
- San Diego is 6-1 on the Run Line this season
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC ...