Our Final Four, National Championship Predictions for March Madness 2025
March Madness is here, bringing the excitement, unpredictability, and potential for stunning upsets that make the NCAA Tournament one of the biggest spectacles in sports. With 68 teams vying for a national championship, anything can happen—Cinderella runs, buzzer-beaters, and championship dreams realized or shattered.
Clemson enters the tournament as a No. 5 seed in the Midwest Region, facing No. 12 McNeese State on Thursday at 3:15 p.m. ET in Providence, Rhode Island. The Tigers (27-6) set program records for total wins, ACC victories (18), and road wins (9) this season. They reached the Elite Eight last year, proving they can make a deep run.
McNeese, riding an 11-game win streak, is a dangerous opponent. If Clemson advances, a potential matchup against No. 4 seed Purdue looms. Elsewhere, top seeds Houston, Auburn, Duke, and Florida aim to avoid early-round upsets.
March Madness never fails to deliver surprises, and this year’s tournament promises plenty. Can a lower seed go the distance? Will the favorites dominate? Only time will tell, but one thing is certain—every game will be must-watch basketball.
Here are our staff predictions for how March Madness will play out.
Turri:
Where Clemson falls: Round of 16 against Houston
Elite 8: Auburn vs. Michigan State, Florida vs. Texas Tech, Duke vs. BYU, Houston vs. Tennessee
Final Four: Auburn vs. Florida, Duke vs. Tennessee
National Championship: Duke vs. Florida
National Champions: Duke Blue Devils
Holley:
Where Clemson falls: Round of 32 against Purdue
Elite 8: Auburn vs. Michigan State, Florida vs. St. Johns, Duke vs. Alabama, Houston vs. Tennessee
Final Four: Michigan State vs. St. Johns, Duke vs. Houston
National Championship: Duke vs. St. Johns
National Champions: Duke Blue Devils
This article originally appeared on Clemson Wire: March Madness 2025 Final Four, National Championship predictions
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