After an 11-week hiatus, the Investec Champions Cup returns on Friday with a thrilling last-16 line-up.
The knockout stages get under way with English champions Northampton Saints taking on Clermont Auvergne under the lights at Franklin's Gardens.
BBC Sport highlights five things to look out for across the weekend.
Champions Cup last 16 fixtures
(All times BST)
Friday, 4 April
Northampton Saints v Clermont (20:00)
Saturday, 5 April
Toulon v Saracens (12:30)
Castres v Benetton (15:00)
Leinster v Harlequins (15:00)
La Rochelle v Munster (17:30)
Glasgow Warriors v Leicester Tigers (20:00)
Sunday, 6 April
Bordeaux-Begles v Ulster (12:30)
Toulouse v Sale Sharks (15:00)
Saracens favour Premiership tilt
Saracens have opted to pursue domestic success over their continental ambitions this season.
The three-time Champions Cup winners have decided to rest several of their England internationals, including Maro Itoje and Tom Willis, for their trip to Toulon.
Director of rugby Mark McCall says he is prioritising making the Premiership play-offs over the chance at a fourth European crown.
Northampton Saints, meanwhile, are the only English side with a home tie after finishing top of Pool 3.
Saints are eighth in the Premiership table after enduring a dismal defence of their title, but Phil Dowson's side will host Clermont in a welcome reprieve from their domestic campaign.
The visitors are sixth in France's Top 14 table after their recent victory over La Rochelle ended a run of five consecutive league defeats.
Clermont booked their place in the knockout stages by snatching a dramatic 33-26 victory in the sixth minute of overtime to qualify at Bath and Bristol's expense.
Elsewhere, Sale Sharks face a daunting trip to six-time winners and defending champions Toulouse, who will be without injured talisman Antoine Dupont after he ruptured cruciate ligaments in his knee during France's Six Nations win over Ireland last month.
Harlequins face an equally difficult task at four-time winners Leinster, while Leicester Tigers travel north to take on Glasgow Warriors.
The full Irish contingent
All three Irish provinces which started in this season's competition have reached the knockout ...
